Bespoke senolytic supplement manufacturing
British VitaTech is a senolytic supplement manufacturer that develops and makes custom fisetin, quercetin and grape seed supplements for brands, led by the markets where each can be sold, and the brand owns the formula.
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Fisetin, quercetin, rutin and grape seed, chosen by where you sell
Led by the markets where each can be sold, we take custom fisetin, quercetin and grape seed supplements for brands from formulation to finished product as a senolytic supplement manufacturer: fisetin formulas for the US, and rutin and grape seed formulas for the UK and the EU. Every format is made in our UK facility: capsules, film-coated tablets, softgels and liposomal formats, powders, sachets and stick packs, and gummies. We design to daily doses with human safety data behind them, and with every batch you receive a certificate of analysis against the agreed specification. Your formula is yours.
Senolytics are compounds that selectively remove senescent cells, and the plant flavonols fisetin and quercetin lead supplement interest in them. The category sits within our healthy ageing and longevity supplement manufacturing.
We specify each flavonol by form, source and purity, and match it to the markets it can be sold in.
| Ingredient | What it is | Where we use it, as of October 2026 |
|---|---|---|
| Fisetin | A flavonol, 3,3',4',7-tetrahydroxyflavone, isolated at 98% or more, for example from smoke tree bark | US products |
| Quercetin | The flavonol itself, supplied as quercetin or quercetin dihydrate | US products |
| Rutin | Quercetin-3-rutinoside, a quercetin glycoside found in many plants | UK, EU and US products |
| Grape seed extract | Standardised to 65% to 95% oligomeric proanthocyanidins | UK, EU and US products |
Fisetin occurs in food at low levels: strawberries, the richest source, hold about 160 µg per gram, and average dietary intake is about 0.4 mg a day (Grynkiewicz and Demchuk, 2019). Supplements therefore rely on isolated fisetin. In the EU, isolated fisetin is a novel food without authorisation, and so is quercetin extracted from Dimorphandra mollis, while rutin and grape seed extract are not novel in food supplements (European Commission, 2026). So we make fisetin products for the US and build EU formulas on rutin and grape seed extract. For the UK, we make the same choice as our own decision: no isolated fisetin, with rutin and grape seed extract instead.
Early human evidence, poor solubility and oxidising flavonols
Senescent cells and the evidence
Senescent cells have stopped dividing but stay active, and they can drive tissue dysfunction linked to ageing (Mayo Clinic, 2024). They resist removal by switching on pro-survival networks. Senolytics were first described in 2015, when researchers found compounds, quercetin among them, that killed senescent cells but spared dividing ones, and a combination cut senescent cell numbers in aged mice (Zhu and colleagues, 2015). In 2018, fisetin was the most potent of 10 flavonoids tested, and late-life dosing extended median and maximum lifespan in mice (Yousefzadeh and colleagues, 2018).
Human evidence is early, and we say so plainly. A randomised trial of a prescription senolytic drug with quercetin, in 60 women, missed its primary endpoint (Farr and colleagues, 2024). Published fisetin studies in people are small and short and measure blood markers (Alipour and colleagues, 2026), and larger fisetin trials run to 2031. Animal results do not become label claims, so we build products on what is settled: ingredient status, dose and quality.
Daily doses, not research regimens
Senolytic research gives doses intermittently, and trials in older adults give fisetin in short, repeated courses. A food supplement carries a fixed daily dose for regular use, so we design to daily doses with human safety data behind them, not to research regimens. A published fisetin trial used 200 mg a day, with no adverse events reported (Alipour and colleagues, 2026). Human safety data for fisetin remain limited, so labels carry an advisory for people who are pregnant, breastfeeding or taking medicines.
Glycosides, complexes and food raise uptake
Quercetin and fisetin dissolve poorly in water; fisetin is practically insoluble, at about 10 µg per ml (Grynkiewicz and Demchuk, 2019). The form changes absorption. In a 2025 meta-analysis of 31 human studies, quercetin oligoglucosides gave about 10 times the bioavailability of rutin and about 20 times that of quercetin itself, a cyclodextrin complex of a quercetin glucoside raised it about 11-fold, lecithin-based systems raised it markedly, and dietary fat and fibre about doubled it (Liu and colleagues, 2025). We pair the form with the market: delivery systems and glycosides for US formulas, and rutin with a direction to take it with food for UK and EU formulas.
Catechol oxidation and yellow colour
Fisetin and quercetin carry a catechol group, which makes them prone to oxidation into quinone-type products, and pH shifts their chemistry (Grynkiewicz and Demchuk, 2019). Both are yellow, so we track colour as well as assay. We protect blends from oxygen, light and moisture, pack in barrier packs with desiccant where needed, and run accelerated stability studies on every new formula in the final pack, with real-time studies when you add them.
Vitamin C and other partners for flavonols
Vitamin C carries the authorised claim "Vitamin C contributes to the protection of cells from oxidative stress" for a product that is at least a source of vitamin C, and it suits flavonol formulas. Brands also combine senolytic candidates with NAD+ precursors, covered on our NAD+ and NMN supplement manufacturing page, and with urolithin A in US products, covered on our urolithin A supplement manufacturing page. Some build them into muscle health formulas too. We check every combination for the total daily dose and each active's status in each market.
How senolytic products are worded for the UK and EU
As of October 2026, fisetin can be sold in US supplements but not in EU ones, and rutin and grape seed extract can be sold in all three markets. No authorised claim refers to senescent cells or ageing. We design every formula to the rules of the markets you sell in.
- Great Britain and the EU: no authorised claim refers to fisetin, quercetin, senescent cells or ageing, so labels carry authorised nutrient claims in exact wording, and packs and marketing make no ageing or senescent cell claims; "senolytic" stays out of the claims. A product presented as clearing cells, or dosed like a medicine, risks being classed as a medicine, so packs and copy follow food supplement rules.
- European Union: isolated fisetin and quercetin from Dimorphandra mollis need novel food authorisation; rutin and grape seed extract do not in food supplements (see the European Commission's novel food catalogue).
- United Kingdom: our own decision, not a GB ruling: we keep isolated fisetin out of UK formulas and use rutin and grape seed extract, as for the EU.
- United States: fisetin and quercetin are sold as dietary ingredients, and FDA had no questions about a GRAS notice for quercetin in foods. Structure and function claims need competent and reliable scientific evidence, a notification to FDA and FDA's standard disclaimer, so we tie claims to what human studies of the ingredient measured.
The "where it can be sold" panel on this page is dated and reviewed every quarter. Our supplement regulation watch and claims and regulation guide cover the rules in more depth.
Capsules for flavonol powders, liposomes for US absorption formulas
As a senolytic supplement manufacturer, we make every format in our UK facility, which is ISO 9001, HACCP and GMP certified by BSI, and FDA registered.
- Capsules: the usual format for flavonol powders, GMP certified, with the dose split across two units where the fill needs it. See capsule and tablet manufacturing.
- Tablets: film-coated to mask taste and add a light and moisture barrier.
- Softgels and liposomal formats: fisetin or quercetin carried in oil or phospholipids, for US formulas built around absorption.
- Powders, sachets and stick packs: grape seed and rutin blends for drinks, with flavour work to mask bitter notes.
- Gummies: yellow flavonols suit citrus and berry flavours, GMP certified, with an active assay on every batch as standard.
Development starts from the format and daily routine your customers want, then sets the ingredient, the form and the dose per unit around it.
Fine yellow powders handled with dust control and full line cleans
- Specify. We set the ingredients, forms, dose, format, markets and claims with you.
- Source. Every flavonol and extract comes from a supplier that has passed our supplier approval, reviewed annually, with a certificate of analysis for each lot. We confirm identity and the source plant before use.
- Weigh and blend. Materials are weighed against the batch record under our allergen management plan with yellow colour coding, with dust control for fine coloured powders and full line cleaning between products, then blended and checked for uniformity.
- Fill or form. Capsules are filled and checked by weight, tablets compressed and film-coated, softgels encapsulated, gummies cooked with the actives added late, and powders sealed into sachets or stick packs.
- Pack. Light and moisture barrier packs, with desiccant where needed.
- Label and release. Label verification on every batch is the critical control point in our HACCP plan, and quality control releases every batch against its specification.
Questions for a senolytic supplement manufacturer about each flavonol
Ask how the flavonol on the label is proved. Every batch is tested by accredited partner laboratories (ISO/IEC 17025) as part of every order, to a specification set per product and market:
- Identity and assay: fisetin, quercetin and rutin by HPLC at release and across shelf life, and grape seed extract against its proanthocyanidin specification.
- Purity: related flavonoids, with the source plant declared for each lot.
- Contaminants: lead, cadmium and mercury against the GB and EU maximum levels for food supplements, residual solvents, and pesticide residues for plant extracts.
- Microbiology and water: total viable count and yeasts and moulds, with water activity for gummies.
With every batch, you receive a certificate of analysis against the agreed specification, and the product file holds the specification, the stability data and the label review for each market. Our quality system adds a HACCP study per product type, reviewed annually; three retained samples per batch, kept for shelf life plus one year; and a full mock recall, forward and backward with mass balance, in seconds. Nothing is dispatched without quality control sign-off, and our testing and batch release page sets out the approach.
Research and development is a paid stage that can be included with an order of the right size. Start your project with your target markets, and we will recommend the ingredients, the format and the dose for each.
References: Zhu and colleagues, Aging Cell (2015); Yousefzadeh and colleagues, EBioMedicine (2018); Farr and colleagues, Nature Medicine (2024); Liu and colleagues, Food Chemistry (2025); Grynkiewicz and Demchuk, Frontiers in Chemistry (2019); Alipour and colleagues, Nutrients (2026); European Commission, novel food status catalogue, fisetin entry (2026).
Where it can be sold
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Fisetin: EU
Not permittedAs of October 2026, isolated fisetin is a novel food without EU authorisation, so it cannot go into EU food supplements.
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Fisetin: US
Permitted with conditionsAs of October 2026, fisetin is sold as a dietary ingredient in US supplements, under the new dietary ingredient rules.
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Quercetin and rutin: EU
Permitted with conditionsAs of October 2026, rutin, a quercetin glycoside, is not novel in EU food supplements, while quercetin extracted from Dimorphandra mollis is a novel food.
-
Quercetin: US
PermittedAs of October 2026, quercetin is sold as a dietary ingredient, and FDA had no questions about a GRAS notice for its use in foods.
Where this is going
To 2030
Flat to up: science grows fast but human results lag (fisetin trials to 2031)
To 2036
Up if senotherapeutic trials succeed, most likely via drug or dermatology routes
What to watch
Little human efficacy data for fisetin, EU novel food status, and safety and classification risk
Questions brands ask
What does the human evidence on senolytics show?
It is early, and we tell brands so plainly. Most senolytic evidence still comes from laboratory and animal studies; published fisetin studies in people are small and short and measure blood markers, and larger fisetin trials run to 2031. So we build products on what is settled: daily doses with human safety data, ingredients with a clear status in each market, every batch tested and claims from authorised nutrients.
Can fisetin be sold in the UK and the EU?
Not in the EU: as of October 2026, the European Commission's catalogue lists isolated fisetin as a novel food without authorisation, so it cannot go into EU food supplements. For the UK, our own decision is to keep isolated fisetin out of UK formulas too and build them on rutin and grape seed extract, which are not novel in EU food supplements. We make fisetin products for the US, where it is sold as a dietary ingredient.
Is quercetin allowed in EU food supplements?
It depends on the form and the source. As of October 2026, rutin, a quercetin glycoside, is not novel in EU food supplements, while quercetin extracted from Dimorphandra mollis is a novel food that needs authorisation. So our UK and EU formulas use rutin, with a direction to take it with food, and our US formulas can use quercetin, its glycosides or delivery systems that raise absorption.
What dose do senolytic studies use, and how do you set ours?
Research gives senolytics intermittently, in short, repeated courses, while a food supplement carries a fixed daily dose for regular use. We design to daily doses with human safety data behind them, not to research regimens; a published fisetin trial used 200 mg a day. Because human safety data for fisetin are limited, labels carry an advisory for people who are pregnant, breastfeeding or taking medicines.
How do you improve quercetin and fisetin absorption?
By choosing the form and the delivery system. A 2025 meta-analysis of 31 human studies found that quercetin oligoglucosides gave about 10 times the bioavailability of rutin and about 20 times that of quercetin itself, a cyclodextrin complex raised it about 11-fold, and dietary fat and fibre about doubled it. Fisetin is practically insoluble in water, so US formulas can carry it in oil or phospholipids, and UK and EU rutin formulas carry a direction to take them with food.
Can the label say the product is senolytic?
Not as a claim in GB or the EU: as of October 2026, no authorised claim refers to senescent cells or ageing, and a product presented as clearing cells risks being classed as a medicine. Labels carry authorised nutrient claims in exact wording instead. In the US, structure and function claims need competent and reliable scientific evidence, so we tie them to what human studies of the ingredient measured.
How do you test senolytic supplements?
Every batch is tested by accredited partner laboratories (ISO/IEC 17025) as part of every order. Tests cover fisetin, quercetin and rutin by HPLC at release and across shelf life, grape seed extract against its proanthocyanidin specification, related flavonoids, lead, cadmium and mercury, residual solvents, pesticide residues and microbiology, with colour tracked in stability studies. Quality control releases every batch, and you receive a certificate of analysis with each one.