Bespoke healthy ageing and longevity supplement manufacturing

Longevity supplement manufacturer for healthy ageing formulas

We are a longevity supplement manufacturer, taking custom healthy ageing supplements for premium brands from formulation to finished product in our Leicester facility. Each formula uses a focused set of actives at studied doses, carries an authorised nutrient claim on GB and EU labels and comes in a format people take every day. That means creatine at 3 g a day for the claim for adults over 55, at least 200 mg of cocoa flavanols a day for the cocoa flavanol claim, and NAD+ formulas built for each market. We make small capsules and tablets, powders, sachets and stick packs, liquids and gummies, designed for older buyers.

People aged 60 and over already account for 27% of global consumer spending (World Data Lab via the World Economic Forum, 2026). A bespoke formula gives a brand its own actives, doses and evidence, and control of its supply. Your formula is yours.

Muscle, NAD+, polyphenols, joints and midlife women

Brands are building five product types.

• Muscle and mobility. Muscle mass and strength fall with age, and the PROT-AGE study group recommends at least 1.0 to 1.2 g of protein per kg of body weight a day for people over 65 (Bauer and colleagues, 2013). Brands answer with protein, creatine, vitamin D and magnesium. See creatine supplement manufacturing.
• NAD+ and cellular energy. NMN for the US, niacin-led formulas for GB and the EU, and urolithin A where a market permits it, often with coenzyme Q10.
• Polyphenols. Cocoa flavanols, pomegranate, grape, berries and pine bark, each standardised to its marker compounds.
• Joints and skin. Collagen with vitamin C, which carries the claim "Vitamin C contributes to normal collagen formation for the normal function of cartilage". See collagen supplement manufacturing.
• Midlife women. In BCG's survey, women in perimenopause or menopause adopted longevity interventions at rates 15 to 22 percentage points higher than other women or men, and roughly a third would spend more on a product or service that showed results (BCG, 2026). See menopause supplement manufacturing.

Formats older buyers can swallow, open and read

Older buyers choose formats they can swallow, open and read. FDA's guidance on generic tablets and capsules cites studies linking sizes above about 8 mm in diameter with more complaints of swallowing difficulty and suggesting that oval tablets may be easier to swallow than round tablets of the same weight. It recommends that a tablet's largest dimension not exceed 22 mm and that capsules not exceed a standard 00 size (FDA, 2022). We design to those limits from the first brief.

• Capsules in smaller sizes, with a dose split across two units where needed, made in-house and GMP certified. See capsule and tablet manufacturing.
• Tablets, film-coated, oval and kept small, are made in-house, as are mini and orodispersible tablets.
• Powders, sachets and stick packs carry gram doses of protein, creatine, collagen and spermidine-rich extract, and are made in Leicester.
• Liquids suit people who would rather not swallow tablets, with flavour work to mask bitter actives. See liquid supplement manufacturing.
• Gummies build a daily habit, with every batch assayed. "Sugar-free" needs no more than 0.5 g of sugars per 100 g, and "reduced sugar" at least 30% less than a similar product, with no more energy. More than 10% added polyols brings the statement "excessive consumption may produce laxative effects".

In GB and the EU, mandatory label information needs an x-height of at least 1.2 mm, or 0.9 mm on packs whose largest surface is under 80 cm². We specify larger type, strong contrast and easy-open packs, such as wide-mouth bottles and push-through blisters, wherever the design allows.

We make every format in our Leicester facility, which is ISO 9001, HACCP and GMP certified by BSI, and FDA registered; capsules, gummies and liquids are GMP certified.

Reconciling NMN by weight and protecting sensitive actives

Every formula runs through our development stages: brief, evidence review, formulation, bench samples, blind sensory panels, a pilot batch on production equipment, stability in the final pack, and scale-up. Each stage leaves a record you keep. Healthy ageing formulas add three controls of their own.

• High-value actives. NMN, urolithin A and spermidine-rich extract are dispensed against the batch record and reconciled by weight, so every gram is accounted for.
• Microgram nutrients. Vitamin D, vitamin K and vitamin B12 are pre-blended with part of the filler, with blend uniformity checked before filling.
• Sensitive actives. Coenzyme Q10, vitamin K2 and polyphenol extracts degrade with light, heat or oxygen, so we specify protected grades, pack against light and confirm the values in stability studies.

Assays that follow the actives, batch by batch

Every batch is tested by accredited partner laboratories (ISO/IEC 17025) as part of every order and released by quality control against its specification; see testing and batch release. The panel follows the actives: assays by HPLC, heavy metals by ICP-MS and microbiology, with an active assay on every gummy batch as standard. Every batch comes with a certificate of analysis and a batch release confirmation, and development adds the formula, the specification with its test methods, stability data and a claims review for each market.

Research context for NAD+, urolithin A and spermidine

We specify every active by form, grade, marker compound and dose, screen it against the EU novel food catalogue and the FSA's register, and approve every supplier before any material is used. The science below is research context, not a product effect: claims come from the register.

NAD+ precursors: NMN and nicotinamide riboside

NAD+ is a coenzyme in energy metabolism, and its levels fall with age in several tissues in animals and humans (Covarrubias and colleagues, 2021). That finding drives demand for precursors such as NMN and nicotinamide riboside. As of October 2026, US supplements can use NMN under the new dietary ingredient rules, while it is not authorised in GB or the EU. For GB and the EU we build on nicotinamide riboside chloride or nicotinamide, both permitted forms of niacin, so labels can carry niacin's authorised claims, and we keep an NMN version ready while EU and GB rules on it are under review. See NAD+ and NMN supplement manufacturing.

Urolithin A and mitochondrial actives

Gut bacteria make urolithin A from ellagitannins and ellagic acid in fruits and nuts, and it is studied as an activator of mitophagy, the clearing of damaged mitochondria (Andreux and colleagues, 2019). Its human trials are small: two published in 2022 enrolled 66 adults aged 65 to 90 and 88 adults aged 40 to 64 (Liu and colleagues, 2022; Singh and colleagues, 2022). In the US, FDA had no questions about a GRAS notice for urolithin A in foods such as protein shakes and bars, and supplements follow the new dietary ingredient rules; it is not authorised in GB or the EU. See urolithin A supplement manufacturing. For every high-value active, the specification sets identity and assay tests, which accredited partner laboratories run on every batch. PQQ disodium salt is an authorised novel food in GB and the EU for food supplements at up to 20 mg a day, for adults excluding pregnant and lactating women.

Spermidine and autophagy

Spermidine, a polyamine in wheat germ, soybeans and nuts, is studied for its role in autophagy, the recycling of cell components (Madeo and colleagues, 2018). Human evidence is thin: in a 12-month trial in 100 older adults, spermidine from wheat germ extract did not improve memory performance against placebo (Schwarz and colleagues, 2022). In GB and the EU, spermidine-rich wheat germ extract is authorised for food supplements at the equivalent of up to 6 mg of spermidine a day, for adults excluding pregnant and lactating women. At the specified 0.8 to 2.4 mg of spermidine per gram, that cap equals 2.5 to 7.5 g of extract, so the assay decides the format.

Polyphenols: cocoa flavanols, resveratrol and botanical extracts

Cocoa flavanols carry an authorised claim that capsules and tablets can use: "Cocoa flavanols help maintain the elasticity of blood vessels, which contributes to normal blood flow". The product must supply at least 200 mg of cocoa flavanols a day, with a degree of polymerisation of 1 to 10, from high-flavanol cocoa extract, and consumers must be told that the effect comes with a daily intake of 200 mg. Trans-resveratrol is authorised in GB and the EU for adult food supplements at up to 150 mg a day; the EU allows any supplement form, while GB specifies capsules or tablets. Pomegranate, grape seed, berry and pine bark extracts have no authorised claims while EU botanical claims stay on hold, so we standardise each extract and let a nutrient carry the label.

Sulforaphane, alpha-ketoglutarate and biological age tests

Sulforaphane forms when the enzyme myrosinase acts on glucoraphanin from broccoli seeds and sprouts. Heat inactivates myrosinase, so formulas pair glucoraphanin with active myrosinase or use a stabilised form (Fahey and colleagues, 2015). Calcium alpha-ketoglutarate (Ca-AKG) draws mainly on mouse research (Asadi Shahmirzadi and colleagues, 2020). Neither has an authorised claim. No authorised claim refers to biological age, so in GB and the EU a product cannot claim to change a test result.

Why healthy ageing needs a specific authorised claim beside it

Claims follow the register, not the research: a longevity formula is limited to the claims of the nutrients it contains. We regard positioning such as "healthy ageing" as a general, non-specific benefit, which in GB and the EU may only be made if accompanied by a specific authorised claim. The table sets out the position as of October 2026, from the GB nutrition and health claims register, the EU register and US law.

One formula can serve all three markets when it is built that way from the start. Start your project with your target markets, and we build the formula and the claims plan together.

NMN and urolithin A under review, and EU dose limits

As of October 2026, these are the points that change what healthy ageing brands can make, sell and claim. We review each line every quarter, and our regulation watch tracks the detail.

• NMN and urolithin A. Both sell in US supplements today; neither is authorised in GB or the EU, where rules on both are under review, so we keep GB and EU versions ready.
• EU vitamin and mineral limits. EU maximum levels for vitamins and minerals in food supplements are under review, so we keep vitamin K, magnesium and other doses in EU formulas ready to step down.

References: US FDA, response to citizen petition on NMN (2025); US FDA, response letter to GRAS notice for urolithin A (2018); Covarrubias and colleagues, Nature Reviews Molecular Cell Biology (2021); Andreux and colleagues, Nature Metabolism (2019); Schwarz and colleagues, JAMA Network Open (2022); Commission Implementing Regulation (EU) 2020/443 (2020); Commission Regulation (EU) 2015/539 (2015); US FDA, guidance on size, shape and other physical attributes of generic tablets and capsules (2022).